ABSTRACT
Atypical Mesoblastic Nephroma (AMN) is a rare infantile renal tumour which may behave aggressively, in contrast to conventional Mesoblastic nephroma. During a 10 year period we encountered four cases of AMN. The mean age of presentation was three months. Size varied from 9-18 cms. All were soft and fleshy with a weight varying from 290-1200 gms. Three cases revealed cystic changes. Hemorrhage and necrosis was seen in all four cases. One case had associated Nephroblastomatosis Complex. The capsule and ureter were involved in one case each. Two of the four patients died of distant metastasis. Thus a close periodic follow up by non-invasive imaging techniques is indicated for early detection of recurrence and or metastasis in cases of AMN.
Subject(s)
Child, Preschool , Female , Humans , Infant , Kidney Neoplasms/congenital , Male , Nephroma, Mesoblastic/congenitalABSTRACT
Six cases of congenital leukemia were encountered in pediatric autopsies carried out over a period of 7 years. The postmortem findings of these cases were analysed and presented along with antemortem peripheral and bone marrow smear. All the cases were diagnosed as acute myeloid leukemia. Gross changes were observed in lungs, liver, spleen and kidneys. Histological abnormalities were detected in these organs as well as the heart, pancreas and intestine. Lymph node follicles were well preserved in all. The thymus showed a normal lobular pattern with interstitial infiltrate. Bone marrow showed myeloid blast cells with depletion of the erythroid and megakaryocytic cells.
Subject(s)
Autopsy , Female , Humans , Infant, Newborn , Kidney/pathology , Leukemia, Myeloid, Acute/congenital , Liver/pathology , Male , Spleen/pathologyABSTRACT
Fibromatosis of thyroid gland is a rare condition encountered in surgical practice. Clinically presenting as goitre, it is treated with near total thyroidectomy with good results. We had one such case under our care at the K.E.M. Hospital, Bombay. Rarity of this condition prompted us to publish the data, the literature is briefly reviewed.
Subject(s)
Fibroma/pathology , Goiter, Nodular/pathology , Humans , Male , Middle Aged , Thyroid Gland/pathology , Thyroid Neoplasms/pathology , ThyroidectomyABSTRACT
Neurogenic tumors of urinary bladder are rare. A ganglionure fibroma arising from the trigons of urinary bladder in two year old boy presenting with hematuria, is described here.
Subject(s)
Child, Preschool , Humans , Male , Neurofibroma/pathology , Urinary Bladder Neoplasms/pathology , Urinary Bladder, Neurogenic/pathologyABSTRACT
A case of malignant melanoma of the nasal cavity is reported. The rarity of its occurrence warrants its mention.
Subject(s)
Aged , Female , Humans , Melanoma/pathology , Nasal Cavity , Nose Neoplasms/pathologyABSTRACT
Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.
Subject(s)
Child, Preschool , Female , Histiocytosis, Langerhans-Cell/metabolism , Humans , Immunohistochemistry , Infant , Infant, Newborn , Male , S100 Proteins/analysisSubject(s)
Abscess/etiology , Adult , Ascariasis , Female , Humans , Omentum , Peritoneal Diseases/etiologyABSTRACT
Strongyloides infection is usually asymptomatic but disseminated infection is a cause of morbidity and mortality in immunodeficient patients. Two fatal cases of strongyloidiasis are reported here, with rare manifestations of gastric ulcers with hematemesis and acute renal failure respectively.
Subject(s)
Child , Child, Preschool , Hematemesis/etiology , Humans , Kidney Diseases/parasitology , Acute Kidney Injury/etiology , Male , Stomach Ulcer/parasitology , StrongyloidiasisSubject(s)
Adult , Child , Female , Humans , Male , Pheochromocytoma/diagnosis , Urinary Bladder Neoplasms/diagnosisABSTRACT
Di-George's syndrome is a rare condition of congenital immunodeficiency. An infant presented as hypocalcemic tetany with multiple infections. Autopsy confirmed the hypoplasia of thymus and thyroid associated with other anomalies. A brief of the relevant literature is presented.